With a little more care to plot holes and a little more attention to making the human characters seem less stupid, Splice could have been a great horror film. While it falls short of that mark, Vincenzo Natalis film about genetic splicing and an experiment gone terribly wrong still has a lot to enjoy. Sarah Polley and Adrien Brody give good performances and manage to make their scientists-in-love couple credible and believable characters despite some serious flaws in both characters judgment and the story has enough to say in order to let us float past the many logical flaws. It is the work of Delphine Chanéac that truly elevates the film though, as she makes the human-hybrid creature Dren a sympathetic, disturbing and wholly mesmerizing character all in one. Natali brings his flair for visuals to the film and provides some fun, gory and unsettling moments amidst all the intellectual posturing. While the film loses steam in the final act and becomes more exploitation than sci-fi horror, the set-ups that the film takes to get there are nifty and the end result is an enjoyable and fairly intelligent horror film. In a market flooded with amped-up yet dumbed-down remakes and joyless drivel when it comes to horror, this is a breath of fresh air despite its flaws.